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Adult ADHD and Comorbid Disorders Many adults with ADHD have comorbid conditions such as major depression (Kessler et al 2006). Many people who suffer from depression do not respond well to medications and may get better results from therapy. Neurotransmitters are brain chemicals that regulate and boost levels of certain brain chemicals. Commonly prescribed stimulants include methylphenidate, amphetamine and other similar drugs. Medicines Adults