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BACKGROUND AND AIMS Endoscopic resection is often feasible for submucosal invasive colorectal cancers (T1-CRCs) and usually judged as complete. If histology casts doubt on the radicality of resection margins, adjuvant surgical resection is advised, although, residual intramural cancer (RIC) is found in only 5% to 15% of patients. We assessed sensitivity of biopsies from the resection area for RIC as a potential tool to estimate the preoperative risk of RIC in patients without risk factors for lymph node metastasis (LNM). METHODS In thi