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The Most Effective ADHD Medication For Adults Stimulants are the first choice of medication for adults with ADHD. They help adjust levels of two chemical messengers in the brain that regulate the ability to pay attention. The most effective treatment for adhd for adults is Strattera (atomoxetine). It is available as capsules that can be taken with food or without. Most people find it efficient. It lasts longer than less powerful stimulants, like methyl