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Our observations already challenged the TIPS therapeutic strategy in BCS secondary to HHHT patients.Background Morcellation may lead to intraperitoneal spread of tumor cells, thus making prognosis of undiagnosed uterine leiomyosarcoma (ULMS) worse. However, preoperative diagnosis of ULMS remains challenging. This study aimed to design a preoperative clinical characteristics scoring system for differentiating ULMS from uterine fibroid. Methods This study enrolled 45 ULMS patients and 180 uterine fibroid patients in Peking Union Medical Co