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Background Telemedicine visits reduce the physical and financial burdens associated with in-person appointments, especially for patients with serious illness. Little is known about patient and caregiver preferences regarding telemedicine visit timing and the discussion of sensitive topics by telemedicine. Objective To characterize the experience of patients with serious illness and their caregivers receiving palliative care (PC) by telemedicine. Design Mixed-methods telephone survey. Setting/Subjects Patients and family caregivers who had