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001). The thyroid volume reduction was also significant (VRR, 42.1% ± 21.1%, 0.001), with moderate consistency between the CT-based thyroid VRR and US-based nodule VRR (ICC = 0.68, 95% confidence interval = 0.38-0.83, 0.001). The mean delivered radiofrequency energy ( = 0.565), number of RFA sessions ( = 0.209), and initial thyroid volume ( = 0.363) showed no significant association with VRR. CT-based quantitative assessments may be useful for evaluating improvements in the neck structures after RFA for benign thyroid nodules. CT-base