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to gap junction-mediated cell-cell communication. This process occurs in a collective of cells but not in that of a single cell. Biophysical properties of ECM induced cell-to-cell communication indicates the importance of microenvironmental mechanics in organ development and diseases. These findings should be of great interest in all biological fields, especially in biomaterials - cell/molecular biology involved in the interactions between the cell and its matrix. Proper wound healing necessitates both coagulation (the formation of a blo