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Dynamic light scattering (DLS) and transmission electron microscopy (TEM) results indicated that the purified PPV-VP2 protein self-assembled into VLPs. Immunogenicity assays in guinea pigs and pigs indicated that the ISA-201 VG adjuvanted PPV-VP2 VLP vaccine elicited hemagglutination inhibition (HI) and virus neutralization (VN) antibody titers comparable with PPV commercial inactivated vaccines, whereas viral loads in the spleen and liver of challenged guinea pigs were significantly reduced. In conclusion, our study provides a method

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But, as soon as global and regional performance of this DAN had been considered we observed (1) higher susceptibility to framing with an increase of inactive time, mediated through reduced local and international performance in the DAN, and (2) lower susceptibility to framing with an increase of inactive time. MVPA was not linked to DMC or graph concept measures. These outcomes declare that continuing to be sedentary may lower neurofunctional preparedness for top-down control and decrease we