https://www.selleckchem.com/pr....oducts/bobcat339.htm
An efficient synthetic method for multisubstituted pyridines from β-aryl-substituted α,β-unsaturated oxime ethers and alkenes via Pd-catalyzed C-H activation has been developed. Systematic optimization of catalyst ligands revealed that sterically hindered pyridines increased the reactivity. Mechanistic studies suggested that the products are formed by Pd-catalyzed β-alkenylation of α,β-unsaturated oxime followed by aza-6π-electrocyclization. Various oximes and alkenes could be utilized to afford multisubstituted pyridines with complet

https://www.selleckchem.com/pr....oducts/17-AAG(Geldan
The 2,923 participants (mean age 76.0±3.9 years, female 52.2%) were categorized into frail (≥3 points, 21.1%), pre-frail (1-2 points, 50.2%) and robust (0 points, 28.7%) groups. Sensitivity (88.3%), specificity (91.6%), and the area under the ROC curve (0.73 for the frail group were sufficient to be accepted as a new frailty scale. The frail group had increased risk of falling (relative risk [RR] 1.810, 95% confidence interval 1.354-2.42, mortality (hazard ratio, 6.596, 1.802-24.137), and IADL decline (RR, 1.638, 1.231-