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178 for GRSCS; = 0.002 and r = 0.176 for GRSWS (higher GRS correlated with lower age of diagnosis.) All HLA GRS showed significant positive associations with age of diagnosis = 0.049 and r = 0.176 for GRCS; = 0.022 and r = 0.176 for GRWS; = 0.022 and r = 0.176 for GRSCS; = 0.011 and r = 0.177 for GRSWS (higher GRS correlated with higher age of diagnosis). Our data suggest that there is a linear relationship between genetic risk and age of SLE diagnosis and that HLA and non-HLA GRS are associated with age of diagnosis in opposite dire
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