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Extended X-ray absorption fine structure shows that FeO length is larger than MnO, but both electron energy loss spectroscopy and X-ray absorption near edge structure indicate that iron is always present as Fe3+ in octahedral sites. These structural modifications may facilitate ionic diffusion during bixbyite formation.The ability to sense changes in oxygen availability is fundamentally important for the survival of all aerobic organisms. However, cellular oxygen sensing mechanisms and pathologies remain incompletely understood and stu