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Most photoresponsive DDSs are merely tuned in to ultraviolet-visible light that shows phototoxicity and/or low structure penetration level, and therefore their particular applications are significantly restricted. To handle these problems, near-infrared (NIR) photoresponsive DDSs happen developed. In this review, the development of NIR photoresponsive DDSs in last several years for cancer photo-chemotherapy are summarized. They could achieve on-demand launch of d