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The interpretability and practical significance of our model are explained in detail in this study. The study on the dynamical changes of Italian region networks reveals the dynamic of COVID-19 transmission at the network level. It is noteworthy that the driving force of MST-DNM only relies on small samples rather than years of time series data. Therefore, it is of great potential in public surveillance for emerging infectious diseases. The study on the dynamical changes of Italian region networks reveals the dynamic of COVID-19 transmi