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RESULTS High density and percentage of proximal CD8+ TILs and low PD-1-to-CD8 ratio had a positive impact on disease-free-survival (P = 0.03) and overall survival (P = 0.003). An inverse correlation was observed between the abundance of intratumoural CD8+ TILs carrying PD-1 inhibitory receptor and cancer cell proliferation. Cases with high compared to low fraction of immune excluded CD8+ TILs had significantly reduced 5-year overall survival (n events 22 vs 12; P = 0.04) and disease-free survival (n events 24 vs 16; P = 0.03) rates while

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How to Fix Common Bifold Doors Repair Problems Bifold doors are stylish and elegant method of connecting living spaces. However, like all door systems they can experience issues that impact their performance. Thoroughly cleaning your bifold doors is important to keep them looking their best. This will also prevent dirt from accumulating and affect their smooth operation. Loose Hinges Contrary to conventional closet doors, bifold doors hinge in the middle and fold in a manner that maximizes space. They have a