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The main aim of the present investigation was the intercalation of WS2 nanosheets in the structure of ceria (CeO2) to be used for the efficient catalytic destruction of tylosin (TYL) as a macrolide antibiotic in water. As-synthesized heterostructured catalyst was placed in a sono-reactor (40 kHz and 300 W) in order to degrade TYL through the sonocatalysis. 15 wt% WS2/CeO2 was chosen for performing the systematic experiments. Decreasing the concentration of TYL, along with increasing the WS2/CeO2 dosage led to reduced degradation effic