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16, 95 % CI 1.08-1.25). For the least exposed façade the HR for Ln 45 vs. ≤ 35 dB was 1.00, 95 % CI (0.95-1.05). For the most exposed façade, the overall association was strongest in smokers and physically inactive. CONCLUSION Long-term residential nighttime noise exposure at the most exposed façade may be associated with a higher likelihood of redeeming prescriptions for sleep medication, especially among men, smokers, and physically inactive. © Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sl

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Coexpression of LRRC8A and LRRC8C gives rise to channels with DCPIB sensitivity that is strongly µ dependent. At normal intracellular µ, LRRC8A + LRRC8C heteromers exhibit strong, voltage-independent DCPIB block that is insensitive to R103F. DCPIB inhibition is greatly reduced and exhibits voltage dependence with low intracellular µ. The R103F mutation has no effect on maximal DCPIB inhibition but eliminates voltage dependence under low µ conditions. Our findings demonstrate that the LRRC8A cryo-EM structure and the use of