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vant immunotherapy with chemotherapy for locally advanced esophageal cancer. Nerve Growth Factor (NGF) is a pivotal mediator of chronic pain and plays a role in bone remodelling. Through its high affinity receptor TrkA, NGF induces substance P (SP) as key downstream mediator of pain and local inflammation. Here we analysed NGF, TrkA and SP tissue distribution in facet joint osteoarthritis (FJOA), a major cause of chronic low back pain. FJOA specimens ( 19) were harvested from patients undergoing intervertebral fusion surgery. Radiolog