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20 pixels on the guidewire dataset and the MPE of 5.30 pixels on the retinal microsurgery dataset, both achieving the state-of-the-art localization results. Besides, the inference rate of our framework is at least 20FPS, which meets the real-time requirement of fluoroscopy images (6-12FPS).Facial expression editing plays a fundamental role in facial expression generation and has been widely applied in modern film productions and computer games. While the existing 2-D caricature facial expression editing methods are mostly realized by ex