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BACKGROUND Many colorectal cancer (CRC) survivors experience persisting health problems post-treatment that compromise their health-related quality of life (HRQoL). Prediction models are useful tools for identifying survivors at risk of low HRQoL in the future and for taking preventive action. Therefore, we developed prediction models for CRC survivors to estimate the 1-year risk of low HRQoL in multiple domains. METHODS In 1458 CRC survivors, seven HRQoL domains (EORTC QLQ-C30 global QoL; cognitive, emotional, physical, role, social functioning; fatigue) w