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Wood Burning Stove - Warmth and Style in One Nothing makes a house feel more at home than the warmth of a wood-burning stove. These heating appliances are more efficient and reliable than electric fireplaces. Created by Danish company Scan, the Novo 24 modern wood stove features an elegant design that can be paired with any style. It can be set directly on the floor or placed on a podium base that creates a convenient storage space for logs. Grappus Designed by Thibault D

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Multiple clinical trials of allogeneic T cell therapy use site-specific nucleases to disrupt T cell receptor (TCR) and other genes1-6. In this study, using single-cell RNA sequencing, we investigated genome editing outcomes in primary human T cells transfected with CRISPR-Cas9 and guide RNAs targeting genes for TCR chains and programmed cell death protein 1. Four days after transfection, we found a loss of chromosome 14, harboring the TCRα locus, in up to 9% of the cells and a chromosome 14 gain in up to 1.4% of the cells. Chromosome 7