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There is a long history uranium mining and milling in what is now the Czech Republic, with the main exploitation beginning in the second half of the 19th century. The greatest expansion was during the cold war and then reduced after political changes in eastern Europe in the 1990s. Thereafter, almost all uranium work was stopped and the mines and mills were closed, and plans for decommissioning and remediation of sites and facilities were initiated. The paper describes the application of the regulatory framework for the decommissioning