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Subgingival microorganisms can orchestrate the microbial community under the influence of environmental factors, thus causing the initiation and progression of periodontitis. Keystone taxa play an important role in the dynamic changes of microbial community. The co-occurrence network analysis may pave the way for screening periodontitis associated candidate keystone taxa in the periodontal microflora. These microorganisms, e.g. Porphyromonas gingivalis, might function via myriad of intermediary taxa or as the chokepoint community-remod