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The complexity of in vivo metabolic activity and biotransformation should therefore be considered in the interpretation of results in vitro and their translation to human physiopathology. To evaluate post-transplantation graft functions noninvasively by using urine C-X-C motif chemokine 10 (CXCL1 and metabolome analysis. The 65 living-donor kidney-transplant recipients in our cohort underwent renal biopsy to investigate possible graft dysfunction. The patients were divided into 2 groups, according to pathology reports chronic allograft