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A systematic review was performed to examine the outcomes of simple hysterectomy for women with low-risk, early-stage cervical cancer. MEDLINE, Embase, Web of Science, and ClinicalTrials.gov were searched from inception until November 4,2020. Original research reporting recurrence or survival outcomes among women with early-stage cervical cancer (defined as stage IA2 to IB1 disease) who were treated with simple hysterectomy. Data regarding study characteristics, tumor characteristics, other treatment modalities, adjuvant therapy, recurre