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ADHD Treatment For Adults - Stimulant Medication Stimulant medications like methylphenidate and dextroamphetamine are generally considered first-line therapy for adult ADHD. These medications balance and increase levels of brain chemicals referred to as neurotransmitters. Antidepressants and nonstimulant medicines, such as atomoxetine, may be prescribed when stimulants aren't appropriate for the patient due to other health issues or adverse effects. These medi