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In the US, community circulation of the SARS-CoV-2 virus likely began in February 2020 after mostly travel-related cases. Children's Hospital of Philadelphia began testing on 3/9/2020 for pediatric and adult patients, and for all admitted patients on 4/1/2020, allowing an early glimpse into the local molecular epidemiology of the virus. We obtained 169 SARS-CoV-2 samples (83 from patients 21 years old) from March through May and produced whole genome sequences. We used genotyping tools to track variants over time and to test for po