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The outcome offered rationale for the development of metabolic biomarkers with diagnostic and prognostic applications utilizing assessment of OXPHOS standing. The metallomic evaluation unveiled the role of disrupted metal homeostasis in ccRCC, highlighting the significance of studying aftereffects of metals from electronic cigarettes and environmental exposures.FUNDINGDepartment of Defense, Veteran Administration, NIH, ACS, and University of Cincinnati Cancer Institute.Myeloid