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molecolar assessment in order to identify target linked to effective and innovative treatment options; it is also highlighted the usefulness of the modern CGP techniques, applicable to tumoral tissue and plasma.To understand how the current organization of the drug evaluation leads to a compartmental vision, and what tools could be added to bring the regulatory activity closer to the goal of include the entire therapeutic path. This is an hard goal but, if we overcome the compartmental approach and open up to tools useful for planning a