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The SCD inhibitor induced the UPR in PANC-1 and suppressed their growth but did not induce cell death. The inhibition of the SCD enzyme causes an UPR and cell death in early pancreatic tumors. The inhibition of the SCD enzyme causes an UPR and cell death in early pancreatic tumors. Circulating cell-free DNA (cfDNA) analysis is recently reported as a promising prognostic biomarker in various types of cancer. This study aimed to evaluate the role of cfDNA in pancreatic head adenocarcinoma. Data for pancreatic head adenocarcinoma undergoing