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We found that the EVs had been enriched utilizing the surface exosomal markers (CD9, СD63, CD81) and an exosome-associated protein HSP70 in situation for the patients with the illness. Proteomic profiling of exosomal proteins did not reveal any proteins connected with PD pathogenesis. Therefore, we revealed that lysosomal disorder in GD patients trigger a striking alteration of plasma exosomes in size and morphology.FLVCR1 encodes for a transmembrane heme exporter necessary protein which is