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78-47.99, p = .0033] and serum MMP-1 levels 6.81 (OR = 2.67, CI = 1.21-6.08, p = .0165). Factors associated with ML current CD4 ≤ 350 (OR = 5.59, CI = 1.69-20.39, p = .006); with LH number of antiretroviral regimens used 2 (OR = 2.06, CI = 1.01-4.20, p = .046 and 3+ (OR = 2.09, CI = 1.00-4.35, p = .0477), and current CD4 ≤ 350 (OR = 2.08, CI = 1.00-4.24, p = .0461); and with LA current viral load 40 (OR = 2.52, CI = 1.03-5.91, p = .0372) and current use of zidovudine (OR = 2.97, CI = 1.32-6.54, p = .0074). Higher levels of MMP