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Both iohexol plasma concentrations (r = 0.98, mean bias -4.20%) and derived GFR values (r = 0.99; mean bias 1.31%), obtained by a conventional plasma and the VAMS method, demonstrated good correlation and acceptable bias. The agreement between the two methods was especially good for GFR values higher than 60 mL/min/1.73 m2. Nevertheless, for GFR values less then 60 mL/min/1.73 m2 the accuracy compared to the plasma method was lower. However, small adjustments to the sampling protocol could probably solve this problem. To stratify the pro