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f breast masses.OBJECTIVE Assess the sensitivity and specificity of computed tomography angiography (CTA) for carotid near-occlusion diagnosis interpreted in clinical practice against expert assessment. METHODS CTAs were graded by two expert interpreters for near-occlusion. Findings were compared with clinical reports in 383 consecutive cases with symptomatic ≥ 50% carotid stenosis. In addition, 14 selected CTA exams (8 near-occlusions and 6 controls) were analyzed in a national effort by 13 radiologists experienced with carotid CTA. RES

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Knockdown of DR5 or overexpression of survivin inhibited combined treatment with IITZ-01 and TRAIL-induced apoptosis. IITZ-01 downregulated protein appearance of Cbl, ubiquitin E3 ligase, and decreased appearance standard of Cbl markedly led to increase DR5 necessary protein expression and TRAIL sensitivity. Furthermore, IITZ-01 decreased appearance amount of survivin protein via downregulation of deubiquitinase ubiquitin-specific protease 9X (USP9X) appearance. Taken together, th