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We use machine optimization to develop a quantum sensing scheme that achieves significantly better sensitivity than traditional schemes with the same quantum resources. Utilizing one-axis twisting dynamics to generate quantum entanglement, we find that, rather than dividing the temporal resources into separate "state-preparation" and "interrogation" stages, a complicated machine-designed sequence of rotations allows for the generation of metrologically useful entanglement while the parameter is interrogated. This provides much higher sen