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Medications and Therapy For ADHD Combining therapy and medication can help manage ADHD. The medication treats the brain while therapy helps people cope and improve their skills. Stimulants such as methylphenidate or Lisdexamfetamine can increase levels of two chemicals that transmit messages between cells within the brain. This can increase attention, impulse control and motivation. The stimulants can trigger negative side effects like loss of appetite, trouble sleeping, and an increas