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Five artificial intelligence (AI) models were benchmarked against MedSeg. The best AI model, ResNet-UNet, was superior to MedSeg by 9% and 15% for Dice and Jaccard, respectively, when compared against MD 1, and by 4% and 8%, respectively, when compared against MD 2. Statistical tests-namely, the Mann-Whitney test, paired -test, and Wilcoxon test-demonstrated its stability and reliability, with 0.0001. The online system for each slice was 1 s. The AI models reliably located and segmented COVID-19 lesions in CT scans. The COVLIAS