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leeding and cardiogenic shock. Our findings are consistent with, and add external validity to, recent randomised trials.Background Targeted ultrasound (US) can be performed to characterize and potentially biopsy areas of enhancement detected on contrast-enhanced mammography (CEM). Objective To determine the utility of targeted US in predicting malignancy of indeterminate or suspicious enhancement on CEM. Methods 1000 consecutive CEM examinations with a same-day targeted breast US performed at our institution between October 2