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C1q levels were reduced in APPNL-G-F compared to WT at all ages and in 3xTg at 12 months; C3 KO and C7 KO, but not Crry KO mice, also demonstrated significantly lower C1q levels compared to matched WT. In brain homogenates, C1q levels increased with age in both WT and APPNL-G-F mice. This robust and adaptable assay for quantification of mouse and rat C1q provides a vital tool for investigating the expression of C1q in rodent models of AD and other complement-driven pathologies.Deactivation processes of photoexcited (λex = 58

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We conclude that APC/CTE plays a key role in regulating plant architecture by mediating the signaling cross talks between ABA and GA. © 2020 American Society of Plant Biologists. All rights reserved.Copy number variations (CNVs) greatly contribute to intraspecies genetic polymorphism and phenotypic diversity. Recent analyses of sequencing data for 1000 accessions of Arabidopsis thaliana were focused on small variations and did not include CNVs. Here, we performed a genome-wide analysis and identified large indels (50-499 bp) and CNV