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In large-annuli SEVs were associated with a lower VARC-2 device success (75.9% vs. 90.6%, p=0.049) driven by a higher rate of paravalvular valvular leak (PVL) compared to BEVs (20.7% vs. 1.2%, p0.001). However, no differences in clinical outcomes were observed according to annular size nor THV type. TAVR in BAV patients is feasible irrespective of annular size. However in patients with large aortic annulus SEVs were associated with a significantly higher rate of PVLs compared to BEVs. TAVR in BAV patients is feasible irrespective of a