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More importantly, we found a limited contribution of power per genome and power per gene to the prokaryote-eukaryote dichotomy. Our findings indicate that the prokaryote-eukaryote divide is hard to explain from the energetic perspective. However, our findings may not entirely discount the traditional hypothesis; in contrast, they indicate the need for more careful examination. © 2020 The Authors.Astyanax mexicanus has gained importance as a laboratory model organism for evolutionary biology. However, little is known about its intermedi