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The principal objective of this paper is to (1) provide a listing of peoples studies that have made use of mind derived neurotrophic factor (BDNF) as a biomarker, (2) review animal studies that help elucidate the mechanistic involvement of BDNF in the development and upkeep of neuropathic discomfort (NP), and (3) provide a critique associated with the present measurement processes to highlight the restrictions associated with techniques utilized to quantify BDNF in different biofluids in the