https://www.selleckchem.com/products/ms-275.html
CKD induces loss of muscle proteins partly by suppressing muscle protein synthesis. Muscles of mice with CKD have increased expression of nucleolar protein 66 (NO66), as do muscle biopsy specimens from patients with CKD or those undergoing hemodialysis. Inflammation stimulates NO66 expression and changes in NF- B mediate the response. Subtotal nephrectomy created a mouse model of CKD with BUN 80 mg/dl. Crossing NO66 with MCK-Cre mice bred muscle-specific NO66 (MCK-NO66) knockout mice. Experiments assessed the effect of removing NO66.
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