https://www.selleckchem.com/ALK.html
Dose response assays revealed nine compounds with submicromolar activity, with slow action activity confirmed for two compounds, alstonine and himbeline (50% inhibitory concentration (IC5 0.17 and 0.58 μM, respectively). Both compounds displayed 140-fold better activity against P. falciparum versus two human cell lines (Selectivity Index (SI) 1,111 and 144, respectively). Importantly, P. falciparum multi-drug resistant lines showed no cross-resistance to alstonine or himbeline, with some resistant lines being more sensitive to these t
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