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It is an unusual instance of huge intramuscular lipoma on tongue. Medical excision with enveloped mucosal flap design was performed to diminish postoperative raw surface and disquiet and a 24-month followup revealed exceptional recovery without the recurrence. A case of intramuscular lipoma on tongue and relevant literary works reviews tend to be presented in this research.The transcriptional coregulator OCA-B promotes expression of T cell target genes in cases of duplicated antigen