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There is minimal information available about bone histomorphometric findings in patients with ankylosing spondylitis (AS). Herein, we report a case of advanced AS complicated with cervical myelopathy due to ossification of yellow ligament (OYL). A 37-year-old Japanese man who had been diagnosed with AS was administered adalimumab. Thirty-four months after adalimumab treatment, he reported upper extremity numbness, dexterity impairment and a spastic gait. Magnetic resonance imaging and computed tomography of the cervical spine revealed cer