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Notably, sST2 is a soluble form of ST2 that lacks a transmembrane domain but preserves an extracellular domain comparable to ST2L, which will act as a "decoy" receptor for IL-33. sST2 has been shown to involve into the inflammatory tumefaction microenvironment additionally the progression of colorectal cancer, non-small cell lung cancer, and gastric cancer tumors. Consequently, concentrating on the IL-33/ST2 axis becomes a promising new immunotherapy for therapy of several typ