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The objective of this study was to describe the case literature of human coronavirus infections in the nervous system of children, including from SARS-CoV-2, and to provide guidance to pediatric providers for managing the potential long-term effects on neurodevelopment of human coronavirus infections in the nervous system. Using a structured strategy, the PubMed and OvidEmbase databases were queried for articles about the clinical presentation and pathophysiology of coronavirus infections in the nervous system of children and young adult