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The agreement with spontaneous attacks and between attacks for headache and its associated symptoms, including laterality, was less reliable. CONCLUSIONS Nitroglycerin can reliably and reproducibly provoke premonitory symptomatology associated with migraine. This forms an ideal model to study the earliest manifestations of migraine attacks.BACKGROUND There is evidence of altered resting hypothalamic activity patterns and connectivity prior to a migraine, however it remains unknown if these changes are driven by changes in overall hypotha