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Thalidomide could ameliorate the histopathological conditions of BDL rats. Additionally, the persistent treatment by this medicine diminished the elevated levels of NO, TNF-α and IL-6 in BDL pets. Having said that, hepatic SOCS1 expression ended up being up-regulated by thalidomide treatment in this team. Conclusion Thalidomide gets better the chronotropic hyporesponsiveness of isolated atria in BDL. This effect is probably mediated by the inhibiting NO, TNF-α and IL-6 production