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62; 95% CI 1.46-10.22; p=.002), smokers/former smokers (OR=6.25; 95% CI 1.70-17.52; p=.005), and implants with no access to interproximal hygiene (OR=7.25; 95% CI 2.20-28.25; p.001). The rate for early and late implant failure in a sample of 190 patients who had received implant therapy in a university setting was 2.1% and 8.9%, respectively, at subject level. Subjects 55years and smokers/former smokers as well as implants with inadequate access to interproximal hygiene were significantly associated with late implant failure. The